See new books on the following topics:

Aging -- Alzheimer's -- Anti-Aging -- Aubrey de Grey Ideas -- Biomedical Nanotechnology -- Brain Aging -- Caloric Restriction -- Cancer -- Cardiovascular Health -- Cryonics -- Dementia -- Diabetes -- Estrogen -- Genetics of Aging and Health -- Geriatrics -- Growth Hormone -- Hormones -- Human Longevity -- Immortality -- Life Expectancy -- Life Extension -- Menopause -- Mortality -- Nursing -- Population Aging -- Regenerative Medicine -- Rejuvenation -- Resveratrol -- SENS: Strategies for Engineered Negligible Senescence -- Stem Cell Therapy -- Supplements -- Testosterone -- Vitamins.

Aging, Longevity and Health in the News

Rich and poor lifespan gap 'widening'
The gap between the lifespans of rich and poor people in England and Wales is rising for the first time since the 1870s, research suggests.

NHS 'failed' man accused of knife murder
A mental health trust admitted failing a man accused of murdering a motorist by stabbing him 39 times on a road in West Sussex, a court is told.

Worsening depression 'link to dementia'
Increasing symptoms of depression in older age could indicate early signs of dementia, say scientists.

Medical errors may be 3rd leading cause of death in U.S.
Most medical errors that lead to death aren't recorded. If they were, we'd know for sure how big a health issue they are.

Half of teens say they're addicted to their phones
I don't have teenagers yet, but watching my 8- and 10-year-olds spend endless amounts of time on iPads during spring break makes me worried about the day -- hopefully years from now -- when they have their own devices.

Want better sleep, better mood, and better sex? Cut calories
Calorie restriction has some positive effects and no negative effects on health-related quality of life, according a new study.

Spate of shootings by children leaves kids, mother dead
The .40-caliber gun stashed under the driver's seat slipped backward on the car floor, right into the reach of Patrice Price's 2-year-old son.

Climbing Everest to shine light on PTSD
A team of veterans and acting soldiers are climbing to the top of Mount Everest to highlight issues affecting veterans once they leave combat, including PTSD and suicide.

Popular: Guns in America | Sanders Demands Clinton Apologize | Blindsided: How ISIS Shook The World

Four immunization innovations saving children's lives
We're in a period marked by the most creative thinking to increase immunization in decades. New approaches to old problems are yielding fresh tools to fight disease.

Teen birth rate hits historic low, but sex ed still a struggle
Teenage girls are catching up to teenage boys in one way that does no one any good: lack of sex education, according to a recent report.

Punished after reporting rape at Brigham Young University
The horror of rape or sexual assault is traumatizing enough for any victim. But for multiple young women at Brigham Young University, they claim they received backlash, instead of support, after reporting sexual violence to the school.

First U.S. Zika death reported
A 70 year old Puerto Rican man died from complications of the Zika virus in February, the Centers for Disease Control and the Puerto Rico Department of Health announced today. This is the first death in the United States or territories where Zika infection contributed to the death, said the CDC.

Mediterranean diet tied to lower risk of heart attack, stroke
The list of Mediterranean diet benefits is getting even longer. A new study found that a diet high in fruits, vegetables, fish and unrefined foods is linked to a lower risk of heart attack and stroke in people who have heart disease.

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Well: Aging in Place
Throughout the country, communities are being retrofitted to accommodate the tsunami of elders expected to live there as baby boomers age.

Global Health: Fight to Prevent a Newborn Infection Receives a Lift
A gel to prevent infections in umbilical cord stumps was endorsed by the European Medicines Agency, a key step to distribution in poor countries.

What Is Alzheimer?s Disease?
Here are answers to some common questions about a disease that can seem frightening, mysterious and daunting.

South Korea Unveils Olympic Uniforms With Zika in Mind
The country?s uniforms for ceremonies, training and time at athletes? village in Brazil will be infused with mosquito repellant.

First U.S. Death Tied to Zika Is Reported in Puerto Rico
An elderly man from Puerto Rico succumbed after complications from an earlier infection caused by the disease-carrying mosquito.

Antismoking Coalition Gives Big Tobacco a Fight in Indonesia
Funding from the Bloomberg Initiative is building local opposition to companies that have eagerly expanded in one of the largest cigarette markets in Asia.

Ties: Seeing the Cycle of Life in My Baby Daughter?s Eyes
We celebrate every moment in an infant?s journey but are repelled by similar helplessness in the elderly.

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Age a factor in youth football concussions, treatment
Study found a range in children's symptoms and how long different age groups spent on the sidelines

Chronic insomnia? Why pills may not be the answer
Before you look to medication to get some much-needed shut-eye, doctors say you should try this first

Half of All Teens Say They're Addicted to Their Phones
The report from Common Sense Media, which studies children's use of technology, is based on a survey of more than 1,200 teenagers and parents.

Can't Sleep? New Study Says Try Therapy, Not Pills
People with insomnia should try counseling before they turn to pills, which often carry dangerous side-effects, a doctors' group advised Monday.

Test Your Risk of Skin Cancer With This Quiz
There are various risk factors for different types of skin cancer, but some people have increased risk if their skin burns easily

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[Editorial] My love-hate of Sci-Hub
Like many scientist-editors of journals published by nonprofit scientific societies, I have a love-hate relationship with Sci-Hub, the website operated out of Russia that provides access to 50 million pirated scientific articles to researchers worldwide (see the News story on p. 508). I recognize the underlying motivation of bringing global research content to the developing world. However, I also recognize that much traffic to Sci-Hub is from researchers who already have access to the articles ...

[In Brief] News at a glance
In science news around the world, the European Commission pledges ?1 billion for its third Flagship project, quantum technologies, the German government extends funding for its Excellence Initiative to create a German "Ivy League" indefinitely, an independent report finds that the Mexican government obstructed an investigation into the disappearance of 43 students from a rural teaching college in 2014, the Spanish National Research Council pushes back against lawsuits levied by postdoc and other...

[In Depth] Critics complain as U.S. shops in Iran's nuclear bazaar
Mere months ago, Iran's nuclear program was an international pariah. Now, it's supplying the U.S. Department of Energy (DOE) with a strategic substance that the United States can't produce. Defying criticism, DOE last week consummated a deal to purchase 32 tons of heavy water?water containing the hydrogen isotope deuterium?from Iran. The $8.6 million sale helps Iran meet a commitment under last July's nuclear deal to shed heavy water, and it will have a swords-to-ploughshares payoff. DOE will re...

[In Depth] Saying no to harassment
The field of physical anthropology recently has been convulsed by several high profile cases of alleged sexual harassment, and by a survey of field scientists showing that harassment during fieldwork is common. So when physical anthropologists gathered last week at their annual meeting, reducing such problems was high on the agenda. But how to change the culture of a discipline? Meeting organizers and advocates offered a menu of actions to battle harassment, from symbolic to concrete. All meetin...

[In Depth] Mexico struggles to woo expat genome jocks
Over the last 10 years, Mexico has invested heavily in training young scientists in genomics and sent many promising students abroad for Ph.D.s and postdocs. The new International Laboratory for Human Genome Research (LIIGH) in Juriquilla, Mexico, which celebrated its first anniversary this month, was built to bring home some of these rising stars. But returnees have been stymied by limited funding and a stifling bureaucracy, and many end up longing for the comparative ease of doing research in ...

[Feature] Who's downloading pirated papers? Everyone
In increasing numbers, researchers around the world are turning to Sci-Hub, the controversial website that hosts 50 million pirated papers and counting. Now, with server log data from Alexandra Elbakyan, the neuroscientist who created Sci-Hub in 2011 as a 22-year-old graduate student in Kazakhstan, Science addresses some basic questions: Who are Sci-Hub's users, where are they, and what are they reading? The Sci-Hub data provide the first detailed view of what is becoming the world's de facto op...

[Feature] The frustrated science student behind Sci-Hub
Beyond being the founder of Sci-Hub, the world's largest pirate site for academic papers, and risking arrest as a result, Alexandra Elbakyan is a typical science graduate student: idealistic, hard-working, and relatively poor. After becoming hooked on science at an early age, she discovered a knack for computer hacking when she went to university in Kazakhstan, where she was born. After a stint in Germany working on brain-computer interfaces, she returned home, where frustrations with journal pa...

[Perspective] A fresh eye on nonequilibrium systems
According to the physicist Richard Feynman, a system is in equilibrium when ?all the fast things have happened but the slow things have not? (1). This definition really applies to a system at steady state, which can either be in thermodynamic equilibrium or in a nonequilibrium steady state. Most systems in nature are not in equilibrium; they exchange fluxes of matter or energy with their surroundings or undergo chemical reactions. When the fast ?things? have happened but the slow ones have not, ...

[Perspective] Liquidity in immune cell signaling
Tlymphocytes of the immune system need to integrate myriad signals to decide on life and death matters in defending the host from pathogens and in distinguishing normal from transformed cells, all while minimizing immunopathology. On page 595 in this issue, Su et al. (1) provide insight into how phase separation of signaling proteins in the two-dimensional (2D) liquid of the plasma membrane enables these critical decisions. Authors: Michael L. Dustin, James Muller

[Perspective] Ionic control of sleep and wakefulness
Brain electrical activity differs markedly between wakefulness and sleep. Concomitant shifts in the ion composition of brain extracellular fluids were thought to be a consequence rather than a cause of the sleep-wake?dependent changes in neuronal activity. On page 550 of this issue, Ding et al. (1) report the surprising observation that ionic changes in the extracellular fluid are a potent control of sleep-wake?dependent neuronal activity. Authors: Hans-Peter Landolt, Sebastian C. Holst

[Perspective] Light flips a membrane-embedded helix
Signaling proteins embedded in cell membranes can transmit information from one side to another, usually by a conformational change within a bundle of transmembrane helices. The challenge of mimicking these proteins with smaller molecules has been picked up by synthetic chemists. On page 575 of this issue, De Poli et al. (1) show that a conformational change in a helical foldamer not only can be elicited by irradiation with light, it can also be allosterically transmitted within a membrane over ...

[Policy Forum] The growing problem of patent trolling
The last decade has seen a sharp rise in patent litigation in the United States; 2015 has one of the highest patent lawsuit counts on record (1). In theory, this could reflect growth in commercialization of technology and innovation?lawsuits increase as more firms turn to intellectual property (IP) protection to safeguard their competitive advantages. However, the majority of recent patent litigation is driven by nonpracticing entities (NPEs), firms that generate no products but amass patent por...

[Technical Comment] Comment on ?Extended-resolution structured illumination i...
Li et al. (Research Articles, 28 August 2015, aab3500) purport to present solutions to long-standing challenges in live-cell microscopy, reporting relatively fast acquisition times in conjunction with improved image resolution. We question the methods? reliability to visualize specimen features at sub?100-nanometer scales, because the mandatory mathematical processing of the recorded data leads to artifacts that are either difficult or impossible to disentangle from real features. We are also co...

[Technical Response] Response to Comment on ?Extended-resolution structured i...
Sahl et al. in their Comment raise criticisms of our work that fall into three classes: image artifacts, resolution criteria, and comparative performance on live cells. We explore each of these in turn. Authors: Dong Li, Eric Betzig

[Special Issue Review] Cross-species comparisons of host genetic associations...
Recent studies in human populations and mouse models reveal notable congruences in gut microbial taxa whose abundances are partly regulated by host genotype. Host genes associating with these taxa are related to diet sensing, metabolism, and immunity. These broad patterns are further validated in similar studies of nonmammalian microbiomes. The next generation of genome-wide association studies will expand the size of the data sets and refine the microbial phenotypes to fully capture these intri...

[Special Issue Review] Resurrecting the intestinal microbiota to combat antib...
The intestinal microbiota, which is composed of diverse populations of commensal bacterial species, provides resistance against colonization and invasion by pathogens. Antibiotic treatment can damage the intestinal microbiota and, paradoxically, increase susceptibility to infections. Reestablishing microbiota-mediated colonization resistance after antibiotic treatment could markedly reduce infections, particularly those caused by antibiotic-resistant bacteria. Ongoing studies are identifying com...

[Editors' Choice] Under pressure in the Magellanic Clouds
Author: Keith T. Smith

[Editors' Choice] Metagenomes yield archaeal metabolisms
Author: Nicholas S. Wigginton

[Research Article] Structure and organization of heteromeric AMPA-type glutam...
AMPA-type glutamate receptors (AMPARs), which are central mediators of rapid neurotransmission and synaptic plasticity, predominantly exist as heteromers of the subunits GluA1 to GluA4. Here we report the first AMPAR heteromer structures, which deviate substantially from existing GluA2 homomer structures. Crystal structures of the GluA2/3 and GluA2/4 N-terminal domains reveal a novel compact conformation with an alternating arrangement of the four subunits around a central axis. This organizatio...

[Research Article] Changes in the composition of brain interstitial ions cont...
Wakefulness is driven by the widespread release of neuromodulators by the ascending arousal system. Yet, it is unclear how these substances orchestrate state-dependent, global changes in neuronal activity. Here, we show that neuromodulators induce increases in the extracellular K+ concentration ([K+]e) in cortical slices electrically silenced by tetrodotoxin. In vivo, arousal was linked to AMPA receptor?independent elevations of [K+]e concomitant with decreases in [Ca2+]e, [Mg2+]e, [H+]e, and th...

[Research Article] Population-level analysis of gut microbiome variation
Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnai...

[Report] Conformational photoswitching of a synthetic peptide foldamer bound ...
The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution. We report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid bilayer akin to a biological membrane phase. These molecules contain a chromophore, which can be switched between two configurations by different wavelengths of light, attached to a helical synthetic peptide that both promotes membrane insertion and ...

[Report] Structure of a bd oxidase indicates similar mechanisms for membrane-...
The cytochrome bd oxidases are terminal oxidases that are present in bacteria and archaea. They reduce molecular oxygen (dioxygen) to water, avoiding the production of reactive oxygen species. In addition to their contribution to the proton motive force, they mediate viability under oxygen-related stress conditions and confer tolerance to nitric oxide, thus contributing to the virulence of pathogenic bacteria. Here we present the atomic structure of the bd oxidase from Geobacillus thermodenitrif...

[Report] RNA splicing is a primary link between genetic variation and disease
Noncoding variants play a central role in the genetics of complex traits, but we still lack a full understanding of the molecular pathways through which they act. We quantified the contribution of cis-acting genetic effects at all major stages of gene regulation from chromatin to proteins, in Yoruba lymphoblastoid cell lines (LCLs). About ~65% of expression quantitative trait loci (eQTLs) have primary effects on chromatin, whereas the remaining eQTLs are enriched in transcribed regions. Using a ...

Infant Colds, Infections and Type 1 Diabetes Risk
Study suggests a link, but researchers still don't understand the potential mechanisms

Seniors' Worsening Depression May Predict Dementia
Study suggests a common underlying cause in some, but not all, cases

Smog May Boost Risk for Several Cancers
Study finds even small increases in pollution raised overall odds of dying from disease by 22 percent

Kids of Older Moms May Have a Leg Up on Peers
They tend to be taller, better educated, and societal changes over time may be behind trend, study suggests

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Basics: Eugenia Cheng Makes Math a Piece of Cake
It can also be a piece of pie, or custard ? so says a professor and author who spreads the magic of numbers through dessert recipes.

Trilobites: The Curious Case of the Caspian Sea?s Scars
A NASA oceanographer saw what appeared to be a scraped seafloor on satellite images of an archipelago.

South Korea Unveils Olympic Uniforms With Zika in Mind
The country?s uniforms for ceremonies, training and time at athletes? village in Brazil will be infused with mosquito repellant.

Dredging of Miami Port Badly Damaged Coral Reef, Study Finds
The report found that as much as 81 percent of the reef near the dredging site was buried in sediment, despite a plan to minimize the damage.

Readers? Responses to a Woman?s Journey Living With Alzheimer?s
More than 100 readers commented on N.R. Kleinfield?s article, ?Fraying at the Edges.? Many of them shared their personal connections with the disease.

What Is Alzheimer?s Disease?
Here are answers to some common questions about a disease that can seem frightening, mysterious and daunting.

First U.S. Death Tied to Zika Is Reported in Puerto Rico
An elderly man from Puerto Rico succumbed after complications from an earlier infection caused by the disease-carrying mosquito.

Further reading: