See new books on the following topics:

Aging -- Alzheimer's -- Anti-Aging -- Aubrey de Grey Ideas -- Biomedical Nanotechnology -- Brain Aging -- Caloric Restriction -- Cancer -- Cardiovascular Health -- Cryonics -- Dementia -- Diabetes -- Estrogen -- Genetics of Aging and Health -- Geriatrics -- Growth Hormone -- Hormones -- Human Longevity -- Immortality -- Life Expectancy -- Life Extension -- Menopause -- Mortality -- Nursing -- Population Aging -- Regenerative Medicine -- Rejuvenation -- Resveratrol -- SENS: Strategies for Engineered Negligible Senescence -- Stem Cell Therapy -- Supplements -- Testosterone -- Vitamins.

Aging, Longevity and Health in the News

Sedentary lifestyle in older women 'ages body cells'
Older woman who do not exercise daily have cells biologically older than their actual age, research suggests.

Real survivors get fairy-tale endings
He seemed like such a nice man, the clean-cut 25-year old who visited a rural Wisconsin church one autumn morning in 1996, looking for a wife.

How to get kids to step up and get involved
Katie Danziger, a mom of three in New York City, remembers when her daughter, a college senior, called last year as there were demonstrations around racial issues on campuses across the country.

Teen with terminal cancer has one final request: Be kind
Seventeen-year-old Rebecca Schofield has three months to a year to live, doctors say. The bold Canadian teen in Riverview, New Brunswick, has cancer, and a final request.

Secret struggles of the friend who's always there for you
A toxic handler is someone who often helps others manage their stress and emotions, but it can become unhealthy if you internalize the woes of others and don't get any support in return, experts say.

GMO apples that never brown could hit stores soon
For a select few apple lovers in the US, a Golden Delicious slice will no longer turn brown as the first genetically modified apples are expected to go on sale early next month.

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The Neediest Cases: After Escape From Syria, Another Dangerous Foe: Diabetes
A Neediest Cases beneficiary agency tries to help bridge a health care gap for a young refugee in Jordan, far from home.

Eat Peppers, Live Longer?
Eating hot chili peppers may help you live longer, a new analysis reports.

Skin cancer cream killed 5 dogs, FDA warns
The agency is warning pet owners to take the following precautions to prevent their pets from accidentally ingesting the topical medication

Insurance equality? States push for cost-free vasectomies
The procedure, which is not covered under current health care law, is increasingly being included in state measures that would require insurers to provide cost-free birth control coverage

These groups less likely to get high blood pressure treatment, study finds
A new study finds racial disparities in treatment of high blood pressure, a risk factor for cardiovascular disease, stroke, and heart attack

Second death in California likely linked to meningitis
The woman was found dead last Tuesday sitting upright in the back of a San Francisco Muni bus

How Working Longer Benefits Health and Finances

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The Neediest Cases: After Escape From Syria, Another Dangerous Foe: Diabetes
A Neediest Cases beneficiary agency tries to help bridge a health care gap for a young refugee in Jordan, far from home.

Eat Peppers, Live Longer?
Eating hot chili peppers may help you live longer, a new analysis reports.

[Research Article] Distortion of histone octamer core promotes nucleosome mob...
Adenosine 5?-triphosphate (ATP)?dependent chromatin remodeling enzymes play essential biological roles by mobilizing nucleosomal DNA. Yet, how DNA is mobilized despite the steric constraints placed by the histone octamer remains unknown. Using methyl transverse relaxation?optimized nuclear magnetic resonance spectroscopy on a 450-kilodalton complex, we show that the chromatin remodeler, SNF2h, distorts the histone octamer. Binding of SNF2h in an activated ATP state changes the dynamics of buried...

[Research Article] The role of dimer asymmetry and protomer dynamics in enzym...
Freeze-trapping x-ray crystallography, nuclear magnetic resonance, and computational techniques reveal the distribution of states and their interconversion rates along the reaction pathway of a bacterial homodimeric enzyme, fluoroacetate dehalogenase (FAcD). The crystal structure of apo-FAcD exhibits asymmetry around the dimer interface and cap domain, priming one protomer for substrate binding. This asymmetry is dynamically averaged through conformational exchange on a millisecond time scale. D...

[In Depth] Science suffers in cold war over polar base
It's summer in Antarctica, the season for science. But at the Princess Elisabeth Antarctica research station, Belgium's futuristic research outpost in East Antarctica, not a single Belgian researcher is at work. A protracted dispute between the Belgian government and the International Polar Foundation, which built and operates the station, has resulted in the cancellation of this year's Belgian expedition to Antarctica. The only scientists to pay a visit so far this year are two scientists from ...

[In Depth] Mixed results from cancer replications unsettle field
The first results of a high-profile effort to replicate dozens of influential papers in cancer biology are roiling the biomedical community. Of the five studies the project has tackled so far, some involving experimental treatments already in clinical trials, only two could be repeated; one could not, and technical problems stymied the remaining two replication efforts. Some scientists say these early findings from the Reproducibility Project: Cancer Biology, which appear this week in eLife, bol...

[Perspective] Unlocking the nucleosome
Almost all eukaryotic genomes are packaged as nucleosomal building blocks that are assembled from an octameric core of histone proteins around which nearly two turns of DNA are wrapped. The apparent homogeneity and stability of nucleosomes has led to their depiction as beads, balls, and other simplifications that imply a largely static histone structural surface on which DNA wraps and unwraps. On page 263 of this issue, Sinha et al. (1) enrich our understanding of nucleosome behavior with direct...

[Perspective] Enzymes at work are enzymes in motion
Enzymes provide the necessary impetus for chemical reactions to occur at a rate that can support biological life. They do so by forming a unique enzyme-substrate complex and thus lowering the energy required for a substrate to convert to a product. Numerous approaches have been used for more than 50 years to unravel the mechanisms of enzyme-mediated catalysis (1). Initial kinetic experiments helped to ascertain substrate specificity. Spectroscopic data have shown that enzymes are not static, and...

[Perspective] Big-data approaches to protein structure prediction
A protein's structure determines its function. Experimental protein structure determination is cumbersome and costly, which has driven the search for methods that can predict protein structure from sequence information (1). About half of the known proteins are amenable to comparative modeling; that is, an evolutionarily related protein of known structure can be used as a template for modeling the unknown structure. For the remaining proteins, no satisfactory solution had been found. On page 294 ...

[Perspective] Chromosomal chaos silences immune surveillance
Not all cancers, and not all individuals with the same cancer type, respond equally to immunotherapy?the use of antibodies to block so-called immune checkpoints in T cells?thereby unleashing immune responses against tumor cells. This can be partially explained by nonsynonymous mutations, which can create neoantigen epitopes that induce T cell responses against cancer cells (1). However, such mutations scattered throughout the genome may or may not activate the immune system, and if they do, thei...

[Book Review] Beyond Schrödinger's cat
According to traditional flight physics, bees should not be able to fly. But fly they do, with mastery of non? steady state aerodynamics and little concern about our limited understanding of their capabilities. Building on recent insights in biophysics research, Furry Logic: The Physics of Animal Life uses a refreshing combination of scientific precision and colloquial wit to show how animals use heat, forces, fluids, sound, electricity, and light to their advantage. Author: Mirko Kovac

[This Week in Science] Filling in the protein fold picture
Author: Valda Vinson

[Report] Scaling carbon nanotube complementary transistors to 5-nm gate lengths
High-performance top-gated carbon nanotube field-effect transistors (CNT FETs) with a gate length of 5 nanometers can be fabricated that perform better than silicon complementary metal-oxide semiconductor (CMOS) FETs at the same scale. A scaling trend study revealed that the scaled CNT-based devices, which use graphene contacts, can operate much faster and at much lower supply voltage (0.4 versus 0.7 volts) and with much smaller subthreshold slope (typically 73 millivolts per decade). The 5-nano...

[Report] Protein structure determination using metagenome sequence data
Despite decades of work by structural biologists, there are still ~5200 protein families with unknown structure outside the range of comparative modeling. We show that Rosetta structure prediction guided by residue-residue contacts inferred from evolutionary information can accurately model proteins that belong to large families and that metagenome sequence data more than triple the number of protein families with sufficient sequences for accurate modeling. We then integrate metagenome data, con...

[Report] Mechanistic basis for a molecular triage reaction
Newly synthesized proteins are triaged between biosynthesis and degradation to maintain cellular homeostasis, but the decision-making mechanisms are unclear. We reconstituted the core reactions for membrane targeting and ubiquitination of nascent tail-anchored membrane proteins to understand how their fate is determined. The central six-component triage system is divided into an uncommitted client-SGTA complex, a self-sufficient targeting module, and an embedded but self-sufficient quality contr...

Many Women With Eating Disorders Do Recover: Study
But it may take years or longer, researchers acknowledge

Childhood Asthma May Encourage Obesity
Fear of flare-ups might spur kids to limit physical activity, specialists say

How Do You Catch a Cold or the Flu?
Arm yourself with these helpful facts to stay healthy all year long.

Skin Cancer Cream Linked to 5 Dog Deaths: FDA
Even ingesting small amounts of fluorouracil can kill family pets, agency warns

Most Cow's Milk Formulas Don't Up Diabetes Risk
But one type of formula may be linked to greater chances if given in week 1, study suggests

Grilled, Smoked Meats and Breast Cancer Survival
Study can't prove cause and effect, but raises questions about beef, pork, lamb cooked at high temps

Too Much Sitting Ages You Faster
Cells of elderly sedentary women look much older than their actual age, study finds

FDA: New Fish Guidelines for Kids, Pregnant Women
Agency recommends 2-3 servings of 'best choices' weekly

High Blood Pressure May Not Be All Bad in Elderly
Developing it after 80 might help prevent mental decline, research suggests

Mold Found in Baby Teething Toy
Mold Found in Baby Teething Toy

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Trilobites: Tasmanian Tigers? Brains Yield Clues Long After Extinction
The last thylacine died in a zoo in 1936, but neural scans of preserved specimens revealed that they may have been more intelligent than previously believed.

A 45.7-Meter Field Goal? The Indy 805K? Florida Stokes the Metric Debate.
Florida?s high schools will apparently become the first in the country to measure field events using the metric system.

Economic Scene: On Climate Change, Even States in Forefront Are Falling Short
States like California and New York have been leaders in curbing carbon emissions from energy. But to achieve their goals, both may need to embrace nuclear power.

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