See new books on the following topics:

Aging -- Alzheimer's -- Anti-Aging -- Aubrey de Grey Ideas -- Biomedical Nanotechnology -- Brain Aging -- Caloric Restriction -- Cancer -- Cardiovascular Health -- Cryonics -- Dementia -- Diabetes -- Estrogen -- Genetics of Aging and Health -- Geriatrics -- Growth Hormone -- Hormones -- Human Longevity -- Immortality -- Life Expectancy -- Life Extension -- Menopause -- Mortality -- Nursing -- Population Aging -- Regenerative Medicine -- Rejuvenation -- Resveratrol -- SENS: Strategies for Engineered Negligible Senescence -- Stem Cell Therapy -- Supplements -- Testosterone -- Vitamins.

Aging, Longevity and Health in the News

Office cake culture is 'danger to health'
Having cake at work to celebrate colleagues' birthdays, engagements or just surviving the week is a danger to health, warns a senior dentist.

Bike versus train: A classic showdown
One of the oldest organized bicycle races in North America competes with a steam train that runs between Durango and Silverton, Colorado.

Popcorn and quinoa are a recipe for long life
Want to live longer? Have a piece of whole grain toast or oatmeal for breakfast, eat popcorn as a snack, or put some buckwheat in your pasta. Two new studies find whole grain may be the key to long life.

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Well: A Poster Family for Diversity
Schools and camps love to feature images of children of different races, but I didn?t want my kids being used to promote an ideal that didn?t exist.

Well: Ask Well: Gun Storage and Children
Asking other parents whether they have guns in their homes ? and how they store firearms ?- can be part of a broader discussion about safety that takes place before a play date.

Opinion: 20-Something, With Menopause
How cancer made me live my life out of order.

Trilobites: What Old Monkeys and Old Humans Have in Common
Monkeys get more picky about certain relationships with age, suggesting biological origins to similar behavior in distantly-related humans.

Tig Notaro finds a way to laugh through the pain
The comedian's brush with death and family tragedy would make most give up on life. Luke Burbank introduces us to female comic who finds humor in just about anything -- sometimes even in life's least funny moments.

Dozens burned at famous motivational speaker's hot coal walk
Motivational speaker Tony Robbins encouraged Dallas conference attendees to walk on hot coals, but some ended up in the hospital

Avoiding Lawnmower Tragedies
Experts say 17,000 children are injured by lawnmowers each year, with hundreds of accidents resulting in amputations. WDIV's Dr. Frank McGeorge

Can I Ever Get Pregnant? Your Questions About Zika
The World Health Organization updated its recommendations on pregnancy, sex and the risk of Zika virus.

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[In Depth] How a ?Godzilla? El Niņo shook up weather forecasts
The 14-month El Niņo climate event that ended this month brought impacts across the globe, from wildfires in Indonesia to drought in Peru. The main drivers of El Niņo conditions, ocean temperatures in the central and eastern Pacific, were as high as 3°C above the average, making this event one of the three most intense El Niņos on record. For the most part, forecasts of its impacts on weather patterns were borne out, but forecasters fared relatively poorly in California, which relies on El Niņos...

[In Depth] California approves publicly funded gun research center
For 2 decades, firearms advocates in Congress have blocked taxpayer-funded research into the causes and consequences of gun violence, which kills more people in the United States than in any other developed nation. Last week, California's state legislature bucked that trend, voting to establish the nation's first publicly funded center for studying gun violence. The new California Firearm Violence Research Center will be run by the University of California system. Its lean budget?$1 million per ...

[Feature] Polar explorer
It is now widely accepted that many animals sense Earth's magnetic field and use it for navigation, and researchers are getting ever closer to the cellular foundations of magnetoreception. But what about humans? Researchers in Tokyo and Pasadena, California, think they have found glimmers of a vestigial sense. Screening out electromagnetic noise, and applying weak magnetic fields on human subjects in a dark, metal box, the researchers think they have found brain waves that signal a passive respo...

[Feature] What and where are the body's magnetometers?
Exactly how animals?and maybe humans?sense Earth's magnetic field is still a mystery. There are two rival explanations, one based on the mineral magnetite working as a mechanical sensor, and another based on the protein cryptochrome as a chemical sensor. Magnetite has turned up in many animal tissues and would provide the sensitivity necessary to respond to minute changes in Earth's field strength, as some animals appear to do. But magnetite could also be a metabolic byproduct. Cryptochrome has ...

[Perspective] Our driverless dilemma
Suppose that a driverless car is headed toward five pedestrians. It can stay on course and kill them or swerve into a concrete wall, killing its passenger. On page 1573 of this issue, Bonnefon et al. (1) explore this social dilemma in a series of clever survey experiments. They show that people generally approve of cars programmed to minimize the total amount of harm, even at the expense of their passengers, but are not enthusiastic about riding in such ?utilitarian? cars?that is, autonomous veh...

[Perspective] How climate change affects extreme weather events
Human-induced climate change has led to an increase in the frequency and intensity of daily temperature extremes and has contributed to a widespread intensification of daily precipitation extremes (1, 2). But has it also made specific extreme weather and climate events?such as floods, droughts, and heat waves?more likely? Although it has been said that individual climate events cannot be attributed to anthropogenic climate change (3), a recent assessment by the National Academies of Science conc...

[Perspective] When the universe became dusty
Observations of the most distant galaxies known are now reaching into the epoch when the first generations of stars were being formed. As stars are the main factories of elements heavier than hydrogen and helium, one also expects to see a reduced abundance of these heavy elements and of the dust that condenses out of them. Recent observations of galaxies within 1 billion years of the Big Bang have shown that the far-infrared (far-IR) emission from dust in these galaxies indeed becomes fainter. A...

[Book Review] Making babies
Two authors have recently sought to enlighten readers on the topic of advances in reproductive technologies: Paul S. Knoepfler, a prolific blogger and well-known stem cell researcher at the University of California, Davis, and Henry T. Greely, professor of law at Stanford University and director of the Center for Law and the Biosciences. Knoepfler's GMO Sapiens is a down-to-earth introduction to the human use of new genetic technologies. An easy and enjoyable read, the book is targeted to an aud...

[Book Review] The best-studied people on the planet
Cohort studies, the empirical longitudinal research of people with a common characteristic, have played a crucial role in enhancing medical care and have dramatically reduced the risk of early death by revealing potential risk factors and unanticipated dangers. In The Life Project, Helen Pearson explores the world's oldest and longest running birth cohort study, which has tracked the lives of five generations of Britons for seven decades. Author: Alireza Salehi Nejad

[Technical Comment] Comment on ?The Atlantic Multidecadal Oscillation without...
Clement et al. (Reports, 16 October 2015, p. 320) claim that the Atlantic Multidecadal Oscillation (AMO) is a thermodynamic response of the ocean mixed layer to stochastic atmospheric forcing and that ocean circulation changes have no role in causing the AMO. These claims are not justified. We show that ocean dynamics play a central role in the AMO. Authors: Rong Zhang, Rowan Sutton, Gokhan Danabasoglu, Thomas L. Delworth, Who M. Kim, Jon Robson, Stephen G. Yeager

[Association Affairs] Panel of experts encourages scientific collaboration wi...
AAAS conference examines partnership potential since signing of nuclear agreement Author: Michaela Jarvis

[This Week in Science] Holding kinases at the ready
Author: Valda Vinson

[Editors' Choice] Macrophages moonlight in brain bleeds
Author: Beverly A. Purnell

[Review] Childhood undernutrition, the gut microbiota, and microbiota-directe...
Childhood undernutrition is a major global health challenge. Although current therapeutic approaches have reduced mortality in individuals with severe disease, they have had limited efficacy in ameliorating long-term sequelae, notably stunting, immune dysfunction, and neurocognitive deficits. Recent work is providing insights about the role of impaired development of the human gut microbiota in disease pathogenesis, leading to new concepts for treatment and prevention. These findings raise intri...

[Research Article] Designer nanoscale DNA assemblies programmed from the top ...
Scaffolded DNA origami is a versatile means of synthesizing complex molecular architectures. However, the approach is limited by the need to forward-design specific Watson-Crick base pairing manually for any given target structure. Here, we report a general, top-down strategy to design nearly arbitrary DNA architectures autonomously based only on target shape. Objects are represented as closed surfaces rendered as polyhedral networks of parallel DNA duplexes, which enables complete DNA scaffold ...

[Research Article] Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 tr...
The Hsp90 molecular chaperone and its Cdc37 cochaperone help stabilize and activate more than half of the human kinome. However, both the mechanism by which these chaperones assist their ?client? kinases and the reason why some kinases are addicted to Hsp90 while closely related family members are independent are unknown. Our structural understanding of these interactions is lacking, as no full-length structures of human Hsp90, Cdc37, or either of these proteins with a kinase have been elucidate...

[Report] Quantum phase magnification
Quantum metrology exploits entangled states of particles to improve sensing precision beyond the limit achievable with uncorrelated particles. All previous methods required detection noise levels below this standard quantum limit to realize the benefits of the intrinsic sensitivity provided by these states. We experimentally demonstrate a widely applicable method for entanglement-enhanced measurements without low-noise detection. The method involves an intermediate quantum phase magnification st...

[Report] Allosteric initiation and regulation of catalysis with a molecular knot
Molecular knots occur in DNA, proteins, and other macromolecules. However, the benefits that can potentially arise from tying molecules in knots are, for the most part, unclear. Here, we report on a synthetic molecular pentafoil knot that allosterically initiates or regulates catalyzed chemical reactions by controlling the in situ generation of a carbocation formed through the knot-promoted cleavage of a carbon-halogen bond. The knot architecture is crucial to this function because it restricts ...

[Report] Single-qubit gates based on targeted phase shifts in a 3D neutral at...
Although the quality of individual quantum bits (qubits) and quantum gates has been steadily improving, the number of qubits in a single system has increased quite slowly. Here, we demonstrate arbitrary single-qubit gates based on targeted phase shifts, an approach that can be applied to atom, ion, or other atom-like systems. These gates are highly insensitive to addressing beam imperfections and have little cross-talk, allowing for a dramatic scaling up of qubit number. We have performed gates ...

[Report] Reprogramming of avian neural crest axial identity and cell fate
Neural crest populations along the embryonic body axis of vertebrates differ in developmental potential and fate, so that only the cranial neural crest can contribute to the craniofacial skeleton in vivo. We explored the regulatory program that imbues the cranial crest with its specialized features. Using axial-level specific enhancers to isolate and perform genome-wide profiling of the cranial versus trunk neural crest in chick embryos, we identified and characterized regulatory relationships b...

[Report] Neuronal subtypes and diversity revealed by single-nucleus RNA seque...
The human brain has enormously complex cellular diversity and connectivities fundamental to our neural functions, yet difficulties in interrogating individual neurons has impeded understanding of the underlying transcriptional landscape. We developed a scalable approach to sequence and quantify RNA molecules in isolated neuronal nuclei from a postmortem brain, generating 3227 sets of single-neuron data from six distinct regions of the cerebral cortex. Using an iterative clustering and classifica...

Diabetes Ups Risk of Heart Attack Death
Study points to need for better coordinated care, more effective use of medications, cardiology specialist says

Healthy Living Slashes Cancer Risk
The 'good' life cuts tumor odds up to 45 percent and risk of cancer death up to 61 percent, study finds

Sprained Ankle May Have Longer-Term Health Effects
Study finds link between adult injury, more heart and lung problems later

Trilobites: Scales, Feathers and Hair Have a Common Ancestor
An ancient reptilian creature was found by researchers to be the source of the spikes, plumage and fur that cover reptiles, birds and mammals.

Trilobites: What Old Monkeys and Old Humans Have in Common
Monkeys get more picky about certain relationships with age, suggesting biological origins to similar behavior in distantly-related humans.

Study Links 6.5 Million Deaths Each Year to Air Pollution
The report, released by the International Energy Agency, urges countries to take steps within their energy industries to help reduce emission levels worldwide.

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